| Rank | Date | Event | County | Deaths | Injuries |
|---|---|---|---|---|---|
| #1 | May 22, 2011 | Tornado EF5 | Jasper County, MO | 158 | 1,150 |
| #2 | Jun 9, 1953 | Tornado F5 | Genesee County, MI | 116 | 785 |
| #3 | May 11, 1953 | Tornado F5 | McLennan County, TX | 114 | 597 |
| #4 | Jun 9, 1953 | Tornado F4 | Worcester County, MA | 90 | 1,228 |
| #5 | May 26, 1955 | Tornado F5 | Cowley County, KS | 75 | 270 |
| #6 | Jul 4, 2025 | Flash Flood | Kerr County, TX | 61 | 0 |
| #7 | Mar 4, 1966 | Tornado F5 | Hinds County, MS | 57 | 504 |
| #8 | Mar 21, 1952 | Tornado F4 | White County, AR | 50 | 325 |
| #9 | Jul 4, 2025 | Flash Flood | Kerr County, TX | 45 | 0 |
| #10 | Apr 27, 2011 | Tornado EF4 | Tuscaloosa County, AL | 44 | 800 |
| #11 | Mar 22, 2014 | Debris Flow | Snohomish County, WA | 43 | 12 |
| #12 | Apr 10, 1979 | Tornado F4 | Wichita County, TX | 42 | 1,700 |
| #13 | Dec 5, 1953 | Tornado F5 | Warren County, MS | 38 | 270 |
| #14 | May 21, 1957 | Tornado F5 | Jackson County, MO | 37 | 176 |
| #15 | Apr 3, 1974 | Tornado F5 | Greene County, OH | 36 | 1,150 |
| #16 | Aug 27, 2017 | Flash Flood | Harris County, TX | 36 | 0 |
| #17 | May 16, 1968 | Tornado F4 | Craighead County, AR | 34 | 350 |
| #18 | Apr 21, 1967 | Tornado F4 | Cook County, IL | 33 | 500 |
| #19 | Apr 9, 1998 | Tornado F5 | Jefferson County, AL | 32 | 258 |
| #20 | Apr 3, 1974 | Tornado F5 | Meade County, KY | 31 | 257 |
| #21 | Apr 11, 1965 | Tornado F4 | Elkhart County, IN | 31 | 252 |
| #22 | Apr 12, 1965 | Tornado F4 | Elkhart County, IN | 31 | 252 |
| #23 | Feb 21, 1971 | Tornado F4 | Humphreys County, MS | 30 | 411 |
| #24 | May 23, 1987 | Tornado F4 | Reeves County, TX | 30 | 121 |
| #25 | Aug 28, 1990 | Tornado F5 | Will County, IL | 29 | 350 |
| #26 | Mar 21, 1952 | Tornado F4 | Woodruff County, AR | 29 | 180 |
| #27 | May 27, 1997 | Tornado F5 | Williamson County, TX | 27 | 12 |
| #28 | Apr 27, 2011 | Tornado EF5 | Franklin County, AL | 27 | 0 |
| #29 | May 12, 1970 | Tornado F5 | Lubbock County, TX | 26 | 500 |
| #30 | Feb 21, 1971 | Tornado F5 | Sunflower County, MS | 25 | 342 |
| #31 | Apr 15, 1956 | Tornado F4 | Jefferson County, AL | 25 | 200 |
| #32 | Feb 23, 1998 | Tornado F3 | Osceola County, FL | 25 | 145 |
| #33 | Apr 27, 2011 | Tornado EF5 | DeKalb County, AL | 25 | 0 |
| #34 | Apr 21, 1967 | Tornado F4 | Boone County, IL | 24 | 410 |
| #35 | Dec 11, 2021 | Tornado EF4 | Graves County, KY | 24 | 210 |
| #36 | May 20, 2013 | Tornado EF5 | Cleveland County, OK | 24 | 207 |
| #37 | Apr 4, 1974 | Tornado F5 | Marion County, AL | 23 | 250 |
| #38 | Mar 22, 1952 | Tornado F4 | Chester County, TN | 23 | 100 |
| #39 | Mar 3, 2019 | Tornado EF4 | Lee County, AL | 23 | 90 |
| #40 | Oct 3, 1964 | Tornado F4 | Lafourche Parish, LA | 22 | 165 |
| #41 | Mar 27, 1994 | Tornado F4 | St. Clair County, AL | 22 | 150 |
| #42 | Apr 4, 1977 | Tornado F5 | Jefferson County, AL | 22 | 130 |
| #43 | Nov 15, 1989 | Tornado F4 | Madison County, AL | 21 | 463 |
| #44 | Jan 9, 2018 | Debris Flow | Santa Barbara County, CA | 21 | 168 |
| #45 | May 16, 1957 | Tornado F4 | Briscoe County, TX | 21 | 80 |
| #46 | Apr 27, 2011 | Tornado EF4 | Jefferson County, AL | 20 | 700 |
| #47 | May 26, 1955 | Tornado F5 | Kay County, OK | 20 | 280 |
| #48 | Nov 6, 2005 | Tornado F3 | Vanderburgh County, IN | 20 | 200 |
| #49 | Apr 12, 1965 | Tornado F4 | Boone County, IN | 20 | 80 |
| #50 | Jun 4, 1958 | Tornado F5 | Dunn County, WI | 20 | 54 |